The SARS-CoV-2 specific memory T cells are likely to be critical for long-term immune protection against COVID-19. We systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in a large cohort of unexposed individuals, as well as exposed family members and individuals with acute or convalescent COVID-19.
SARS-CoV-2-specific T cells in acute phase show a highly activated cytotoxic phenotype that correlated with several clinical markers of disease severity, while SARS-CoValunctional-specific T cells were convaluncient and exhibited a phenotype. stem-like memory.
Importantly, SARS-CoV-2-specific T cells were detectable in antibody seronegative family members and in people with a history of mild or asymptomatic COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses similar to those seen in the context of successful vaccines, suggesting that natural exposure to infection may prevent recurrent COVID-19 episodes. severe also in seronegative individuals.
“This is very promising,” says Smita Iyer, an immunologist at the University of California at Davis. “This requires some sober optimism about herd immunity and potentially a vaccine.”
For a long time it was thought that antibodies protected against re-infection, but the first study to use solid real-world evidence was published last week by researchers at the University of Washington.
|Ciudad||Estimado de Anticuerpos|
|Nueva Delhi y Mumbai||24%|